Advances in Membranous and Membranoproliferative glomerulonephritis: Insights into Pathogenesis
نویسنده
چکیده
Membranous glomerulonephritis is characterised by accumulation of immune complexes on the outside of the glomerular basement membrane. This leads to development of projections of the membrane adjacent to the deposits which eventually become incorporated into the membrane. In about 20% of cases the disease occurs in association with another condition such as SLE, cancer or drug exposure. The remaining cases are referred to as idiopathic. It is the most common cause of idiopathic nephrotic syndrome in Caucasian adults.
منابع مشابه
Rituximab for Treatment of Membranoproliferative Glomerulonephritis and C3 Glomerulopathies
Membranoproliferative glomerulonephritis (MPGN) is a histological pattern of injury resulting from predominantly subendothelial and mesangial deposition of immunoglobulins or complement factors with subsequent inflammation and proliferation particularly of the glomerular basement membrane. Recent classification of MPGN is based on pathogenesis dividing MPGN into immunoglobulin-associated MPGN a...
متن کاملMantle Cell Lymphoma associated with Membranoproliferative and Membranous Glomerulonephritis: Report of Two Cases
Mantle Cell Lymphoma associated with Membranoproliferative and Membranous Glomerulonephritis: Report of Two Cases Elena Zakharova1*, Ekaterina Stolyarevich2, Eugeny Nikitin3 1Nephrology Department, Head, Moscow City Botkin Memorial Hospital 2Nephropathology Department, Head, Moscow City Nephrology Centre 3Hematology Day Patient Department, Head, Moscow City Botkin Memorial Hospital Cancer Scien...
متن کاملA Rare Case of Castleman’s Disease of Plasma Cell Type Complicated with Membranoproliferative Glomerulonephritis
Castleman’s disease (CD) is an uncommon atypical lymphoproliferative disorder with different histological and clinical forms. Patients with the plasma cell type frequently present with systemic symptoms; including fever, weight loss, hemolytic anemia, hypoalbuminemia, hypergammaglobulinemia and increased acute-phase proteins. Renal manifestations like proteinuria or hematuria are common in Cast...
متن کاملAutoimmune kidney diseases.
The second most common cause of chronic renal failure is glomerulonephritis, which is a collective term used for numerous diseases with the common denominator of histological renal inflammation emanating from the glomerular tuft. Whether all forms of glomerulonephritis should be considered as autoimmune disease is debatable, but immune mechanisms are important in all of them. This review focuse...
متن کاملAnti-Glomerular Basement Membrane Disease Accompanied by Membrano Proliferative Glomerulonephritis: A Case Report
Anti-glomerular basement membrane disease is characterized by autoimmunity to antigenic sites on type IV collagen of the glomerular basement membrane. The majority of patients present with rapidly progressive glomerulonephritis and alveolar hemorrhage. The occurrence of antiglomerular basement membrane disease and other types of glomerulonephritis, such as membranous nephropathy, IgA nephropath...
متن کامل